5(6)-Carboxyfluorescein, For Fluorescenc E
3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-ar-carboxylic acid
CAS: 72088-94-9;80537-70-8;94595-55-8
Molecular Formula: C42H24O14
5(6)-Carboxyfluorescein, For Fluorescenc E - Names and Identifiers
| Name | 3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-ar-carboxylic acid |
| Synonyms | 5(6)-FAM 5(6)-CARBOXYFLUORESCEIN 5(6)-Carboxyfluorescein 4(5)-Carboxyfluorescein 4(5)-CARBOXYFLUORESCEIN 5-(AND-6)-CARBOXYFLUORESCEIN 5-(And-6)-Carboxyfluorescein 5(6)-CARBOXYFLUORESCEIN, FOR FLUORESCENC E 5(6)-Carboxyfluorescein, For Fluorescenc E 3',6'-dihydroxy-1-oxo-spiro[isobenzofuran-3,9'-xanthene]-5-carboxylic acid 9'-[9h]xanthene]-ar-carboxylicacid,3',6'-dihydroxy-spiro[isobenzofuran-1(3h 3',6'-dihydroxy-3-oxo-spiro[isobenzofuran-1,9'-xanthene]-5-carboxylic acid 9'-[9H]Xanthene]-Ar-Carboxylicacid,3',6'-Dihydroxy-Spiro[Isobenzofuran-1(3H 3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-ar-carboxylic acid 3',6'-Dihydroxy-3-oxospiro(isobenzofuran-1(3H),9'-(9H)xanthene)-ar-carboxylic acid Spiro(isobenzofuran-1(3H),9'-(9H)xanthene)-ar-carboxylic acid, 3',6'-dihydroxy-3-oxo- |
| CAS | 72088-94-9 80537-70-8 94595-55-8 |
| EINECS | 276-331-1 |
| InChI | InChI=1/2C21H12O7/c22-11-2-5-15-17(8-11)27-18-9-12(23)3-6-16(18)21(15)14-4-1-10(19(24)25)7-13(14)20(26)28-21;22-11-2-5-14-17(8-11)27-18-9-12(23)3-6-15(18)21(14)16-7-10(19(24)25)1-4-13(16)20(26)28-21/h2*1-9,22-23H,(H,24,25) |
| InChIKey | CPRVUBZYHZGASQ-UHFFFAOYSA-N |
5(6)-Carboxyfluorescein, For Fluorescenc E - Physico-chemical Properties
| Molecular Formula | C42H24O14 |
| Molar Mass | 752.63 |
| Density | 1.3418 (rough estimate) |
| Melting Point | 275 °C |
| Boling Point | 464.9°C (rough estimate) |
| Water Solubility | slightly soluble |
| Solubility | DMSO (Sparingly), Methanol (Slightly, Heated) |
| Appearance | Orange powder |
| Color | Light Yellow to Dark Brown |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Sensitive | Sensitive to light and humidity |
| Refractive Index | 1.6380 (estimate) |
| MDL | MFCD00151081 |
| Physical and Chemical Properties | Pinene, colorless oily liquid. Relative density 0.858-860, boiling point 156-157 ℃, refractive index 1.4658-1.4670, soluble in ethanol and oil flavor. Ethylpinene, colorless oily liquid, relative density 0.870, boiling point 164-166 ℃, refractive index 1.4755-1.4872, soluble in ethanol and oil. There is mild resin fragrance with cool pine needle breath. The aroma of the hair, but not long. |
| Use | It is an important starting material for the synthesis of terpene spices, such as linalool, geraniol, citronellol, ionone, borneol, camphor and so on. Can be used in a small amount of clove and other flower flavor and pine needle type, a very small amount of lemon, bergamot, nutmeg, fragrant leaves, lavender and other fragrance types. Trace for food flavor, such as lemon, nutmeg and other flavors. |
| In vitro study | 5(6)-Carboxyfluorescein has two main characteristics: it has two wavelengths of maximum absorbance (465 and 490 nm) and its fluorescence emission (maximum, 515 nm) increases as a function of pH in the physiological pH range of 6-7.4. |
5(6)-Carboxyfluorescein, For Fluorescenc E - Risk and Safety
| Risk Codes | R36 - Irritating to the eyes R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S22 - Do not breathe dust. |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29322090 |
5(6)-Carboxyfluorescein, For Fluorescenc E - Introduction
Under alkaline conditions, it has strong green fluorescence and fluorescent probe materials, which are widely used in fluorescence analysis, tracer dyes, PH indicators and derivatives of carboxyl fluorescein.
Last Update：2022-10-16 17:28:10
5(6)-Carboxyfluorescein, For Fluorescenc E - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| biological activity | 5(6)-carboxy fluorescein (5(6)-FAM) it is an amine-reactive pH-sensitive green fluorescent marker. 5(6)-carboxy fluorescein can be used to label proteins, polypeptides and amino acids. 5(6)-carboxy fluorescein can be used for in vivo experimental tumor location detection. |
| Animal Model: | CDF mice, bearing lymphoid leukemia P388 |
| Dosage: | 5 mg/kg |
| Administration: | Injected intraperitoneally |
| Result: | Could be used for measurement and imaging of tumor tissue. |
| Use | is a synthetic terpene flavor such as linalool, geraniol, citronellol, citral, ionone, borneol, important starting materials such as camphor. Can be used in a small amount of clove and other flower flavor and pine needle type, a very small amount of lemon, bergamot, nutmeg, fragrant leaves, lavender and other fragrance types. Trace for food flavor, such as lemon, nutmeg and other flavors. fluorescent probe materials, which have strong green fluorescence under alkaline conditions, are widely used in fluorescence analysis, Tracer dyes, PH indicators and synthesis of carboxyl fluorescein derivatives. Intracellular PH probe. |
Last Update：2024-04-09 21:21:28
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